An Unstable Haemoglobin with Reduced Oxygen Affinity: Haemoglobin Peterborough, (βiii (G13) Valine → Phenylalanine, its Interaction with Normal Haemoglobin and with Haemoglobin Lepore

Abstract

Summary: A new unstable haemoglobin, Hb Peterborough, is described in father and son. In the former it was found with Hb A but in the latter with Hb Lepore, the mother being a heterozygote for Hb A and Hb Lepore Boston (or Washington). In this respect it differs from other unstable haemoglobins so far described which have been observed in heterozygotes together with normal adult haemoglobin. It was therefore possible to compare the clinical and biochemical interactions of Hbs A and Peterborough, A and Lepore, and Peterborough and Lepore. Hb Peterborough has been identified as βiii (G‐13) Val → Phe. It has a low oxygen affinity, but the Bohr effect and haem‐haem interaction appear to be normal.