Intraepithelial expression of perlecan, a basement membrane‐type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium

Abstract

The findings indicate that perlecan is localized in the intercellular space of the oral epithelia, and that it is over-expressed in dysplastic epithelial cells and is deposited in their interepithelial space, which results in the histology of reduction of cellular cohesion.