Nitric Oxide

Abstract

Rat serosal mast cells were tested for their ability to generate a nitric oxide (NO)-like factor by two bioassay systems: inhibition of platelet aggregation and stimulation of mast cell guanylate cyclase. The relationship between histamine release and NO-like activity from these cells was also investigated. Incubation with human washed platelets of rat serosal mast cells treated with indomethacin resulted in an inhibition of thrombin-induced platelet aggregation proportional to the number of cells.