Hormone and Metabolic Research · 1977 · 15 citations · 0 references
MedicineEndocrinologyPharmacologyClinical PharmacologyPharmacodynamicsReproductive EndocrinologyGrowth HormoneHormone ReleaseHormone SecretionHypothalamic-pituitary RegulationPituitary Gland FunctionPituitary HormonesGrowth Hormone Stimulation TestsHypothalamic Regulation Of ProlactinHypothalamic-pituitary-prolactin AxisMale Prolactin PhysiologyPaired T-testPhysiological HyperprolactinemiaProlactin PharmacologyProlactin Secretion Regulation
Paired TRH (thyrotropin releasing hormone) and CPZ (chlorpromazine) stimulation tests were performed on 3 and 5 normal male volunteers respectively. During one of the paired tests, Intralipid plus heparin was administered i.v. for 3 hours to assess the effect of FFA and TG elevations on prolactin (PRL) secretion. At the end of the first hour of Intralipid plus heparin (or saline for control stimulations), either CPZ (25 mg i.m.) or TRH (250 units i.v.) was given. In the Intralipid experiments, plasma TG and FFA values more than doubled. The PRL responses to CPZ and TRH were not significantly affected by the lipid infusion. In addition, intravenous lipid did not suppress the elevated prolactin levels observed in drug induced chronic hyperprolactinemia.