Metabolism and activation of cyclopenta polycyclic aromatic hydrocarbons in liver tissue from rats and humans

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

Bruce N. Ames, Joyce McCann, Edith F. Yamasaki · Mutation Research/Environmental Mutagenesis and Related Subjects · 1975 · 7.4K citations

Medicine, Genetics, Pathogenesis +10

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Peter Sims, P.L. Grover, Alan Swaisland et al. · Nature · 1974 · 1.1K citations

Biochemistry, Metabolic Activation, Metabolism +3

32P-labeling test for DNA damage.

Kurt Randerath, M Vikram Reddy, Ramesh C. Gupta · Proceedings of the National Academy of Sciences · 1981 · 532 citations · Full text

Dna Damage, Propylene Oxide, Dna Analysis +16

Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.

Ramesh C. Gupta · Proceedings of the National Academy of Sciences · 1984 · 520 citations · Full text

Molecular Biology, Pathology, Toxicological Mechanism +20

Enhanced sensitivity of 32P-postlabeling analysis of aromatic carcinogen:DNA adducts.

Ramesh C. Gupta · PubMed · 1985 · 473 citations

Molecular Characterization, Nucleic Acid Biomarkers, Biochemistry +13