Absence of Intercapillary Glomerulosclerosis in the Diabetic Patient with Hemochromatosis

Abstract

THE genesis of the Kimmelstiel–Wilson lesion and, for that matter, of all the vascular lesions in diabetes mellitus is not understood. It is unclear whether the pathogenesis of the vascular changes is intimately connected to the carbohydrate defect, or whether there is a dissociation of the two. As Ricketts1 has put it, there are three possibilities: vascular disease may cause diabetes; diabetes may cause vascular disease; some common factor may cause both the diabetes and the changes in the blood vessels.Dolger2 more or less concurs in this last view by stating that arteriosclerosis, hypertension and diabetes may have a . . .