Concepedia

Cytosporolides A−C, Antimicrobial Meroterpenoids with a Unique Peroxylactone Skeleton from <i>Cytospora</i> sp.

Yan Li, Subin Niu, Bing‐Da Sun, Shuchun Liu, Xingzhong Liu, Yongsheng Che

Organic Letters · 2010 · 59 citations · 26 references

DOI

Abstract

Cytosporolides A-C (1-3), three caryophyllene-derived meroterpenoids with a unique peroxylactone skeleton, were isolated from cultures of the fungus Cytospora sp. Their structures were elucidated by NMR spectroscopy, and the absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke's method. Compounds 1-3 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Streptococcus pneumoniae.

References

26

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