Science · 2002 · 1K citations · 26 references
EngineeringBioengineeringChemical EngineeringCapsule TechnologyDrug DeliveryNanotechnologyDrug EncapsulationMicrofluidic Device FabricationMicrofluidic DevicesMicrofluidic SystemsMicrofluidicsCapsule FabricationEncapsulationJet BreakupMicrocapsule SizeMicroencapsulation ProcessesMicrofluidic Droplet Generation
We report a method to generate steady coaxial jets of immiscible liquids with diameters in the range of micrometer/nanometer size. This compound jet is generated by the action of electro-hydrodynamic (EHD) forces with a diameter that ranges from tens of nanometers to tens of micrometers. The eventual jet breakup results in an aerosol of monodisperse compound droplets with the outer liquid surrounding or encapsulating the inner one. Following this approach, we have produced monodisperse capsules with diameters varying between 10 and 0.15 micrometers, depending on the running parameters.
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Biodegradable Long-Circulating Polymeric Nanospheres
Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia et al. · Science · 1994 · 2.9K citations
Biologically erodable microspheres as potential oral drug delivery systems
Edith Mathiowitz, Jules S. Jacob, Yong S. Jong et al. · Nature · 1997 · 824 citations