Changes in Brain Tissue Oxygenation After Treatment of Diffuse Traumatic Brain Injury by Erythropoietin*

Abstract

Our findings indicate that brain hypoxia can be related to microcirculatory derangements and cell edema without evidence of brain ischemia. These changes were reversed with post-traumatic administration of recombinant human erythropoietin, thus offering new perspectives in the use of this drug in brain injury.