Haterumadysins A−D, Sesquiterpenes from the Okinawan Marine Sponge <i>Dysidea </i><i>c</i><i>hlorea</i>

Abstract

Haterumadysins A-D (1-4) and two known compounds, spirodysin (5) and dehydroherbadysinolide (6), were isolated from the sponge Dysidea chlorea. Their structures were successfully determined by detailed spectroscopic analysis. Compounds 1-5 all showed the ability to inhibit the division of fertilized sea urchin eggs.