Journal Of Clinical Periodontology · 2012 · 10 citations · 19 references
DentistryOral BiologyGenetic EpidemiologyMolecular EpidemiologyPeriodontal MedicineEpidemiology Of Oral DiseasesGenetic Susceptibility To PeriodontitisMatrix Metalloproteinase GeneticsPeriodontal DiseaseMatrix Metalloproteinase 9 GeneticsMatrix Metalloproteinase Gene PolymorphismsMatrix Metalloproteinase Genetic SusceptibilityMatrix Metalloproteinase Single Nucleotide PolymorphismsMatrix MetalloproteinasesPeriodontitis PathogenesisPeriodontitis SusceptibilityPooled Odds Ratios
AIM: The study was conducted to explore the potential association of Matrix metalloproteinases (MMP)-9 -1562C>T with susceptibility to periodontitis. MATERIALS AND METHODS: Electronic literature searches of PubMed, EMBASE and EBSCO databases were performed. Fixed-effects or random-effects models were used to calculate the pooled odds ratios (ORs) for four genetic comparisons. RESULTS: Seven eligible studies with a total of 628 cases and 689 controls were recruited in the pooled analysis. We found MMP-9 -1562C>T contributed to decreased risk of chronic periodontitis. Furthermore, the polymorphism was associated with modified risk of periodontitis among Caucasian populations. CONCLUSIONS: This study indicated that MP-9 -1562C>T might be involved in the development of periodontitis. A replication of our results in independent large analysis populations is necessary to give evidence to our observation.
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Bias in meta-analysis detected by a simple, graphical test
Matthias Egger, George Davey Smith, Martin Schneider et al. · BMJ · 1997 · 56.3K citations