Amygdala kindling in the rat: anxiogenic-like consequences

Modification of seizure activity by electrical stimulation: II. Motor seizure

Ronald J. Racine · Electroencephalography and Clinical Neurophysiology · 1972 · 7.2K citations

Medicine, Neurology, Neuroscience +16

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.8K citations

Social Sciences, Behavioral Sciences, Psychology +9

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

A permanent change in brain function resulting from daily electrical stimulation

Graham V. Goddard, Dan McIntyre, Curtis K. Leech · Experimental Neurology · 1969 · 3.1K citations

Life Sciences, Neurology, Neuroscience +16

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Paul Willner, Anthony Towell, D. Sampson et al. · Psychopharmacology · 1987 · 2K citations

Medicine, Behavioral Sciences, Pharmacology +15