Alterations in tumour suppressor gene p53 correlate with inhibition of thrombospondin-1 gene expression in colon cancer cells

Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.7K citations

Tumor Biology, Somatic Variant, Tumor Heterogeneity +13

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

Tumor Biology, Cancer Pathology, Molecular Pathogenesis +9

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

Kristina M. Dameron, Olga V. Volpert, Michael A. Tainsky et al. · Science · 1994 · 1.4K citations

Wild-type P53 Inhibits, Pathology, P53 Regulation +16

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

Deborah J. Good, Peter J. Polverini, Farzan Rastinejad et al. · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations · Full text

Immunology, Pathology, Tumor Biology +17

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

Janusz Rak, Yoshihiro Mitsuhashi, Liisa Bayko et al. · PubMed · 1995 · 768 citations

Vegf/vpf Activity, Solid Tumor Growth, Angiogenesis +15