Synthesis, enzyme — substrate interaction, and herbicidal activity of phosphoryl analogues of glycine

Abstract

Abstract The interactions of hydrophosphoryl compounds 1 – 10 and 1,3,5‐triacetylhexahydro‐1,3,5‐triazine furnish the N ‐acetylated (aminomethyl)phosphoryl compounds 11–20 , which, upon acidic hydrolysis, lead to 3, 6, 9 , and 21 – 24 . Strict selectivity is observed in the enzyme‐catalyzed hydrolysis with the enzymes α‐chymotrypsin, phosphodiesterase I, and alkaline phosphatase. Some of the synthesized materials exhibit herbicidal and antitumor activity.