Anaphylactoid Reactions to Oral Administration of Penicillin

Abstract

PENICILLIN reactions may be immediate, delayed or accelerated. Those that are immediate occur within minutes of the administration of the agent; the others take place much later. The term "anaphylactoid reactions" refers only to severe immediate systemic reactions associated with hypotension and often a shocklike state.The possibility of an anaphylactoid reaction to parenterally administered penicillin is well known. Reactions of all types seem to be more prevalent after the parenteral than after the oral therapy. However, reactions to oral administration occur, and these may reach alarming proportions.Few studies of the incidence of penicillin reactions have been made, but . . .