Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

John T. Groves, Gary A. McClusky, Ronald E. White et al. · Biochemical and Biophysical Research Communications · 1978 · 538 citations · Full text

Life Sciences, Biochemistry, Cellular Metabolism +11

Hydroxylation of linear alkanes catalysed by iron porphyrins: particular efficacy and regioselectivity of perhalogenated porphyrins

J.F. Bartoli, Olivier Brigaud, Pierrette Battioni et al. · Journal of the Chemical Society Chemical Communications · 1991 · 115 citations

Natural Sciences, Biochemistry, Chemistry +10

Synthesis of a highly stable iron porphyrin coordinated by alkylthiolate anion as a model for cytochrome P-450 and its catalytic activity in oxygen-oxygen bond cleavage

Tsunehiko Higuchi, Shinobu Uzu, Masaaki Hirobe · Journal of the American Chemical Society · 1990 · 112 citations

Life Sciences, Biochemistry, Chemistry +16

Heterolytic oxygen-oxygen bond cleavage of peroxy acid and effective alkane hydroxylation in hydrophobic solvent mediated by an iron porphyrin coordinated by thiolate anion as a model for cytochrome P-450

Tsunehiko Higuchi, Kousei Shimada, Naho Maruyama et al. · Journal of the American Chemical Society · 1993 · 88 citations

Life Sciences, Biochemistry, Chemistry +16

Pronounced Axial Thiolate Ligand Effect on the Reactivity of High-Valent Oxo−Iron Porphyrin Intermediate

Yasuteru Urano, Tsunehiko Higuchi, Masaaki Hirobe et al. · Journal of the American Chemical Society · 1997 · 83 citations

Natural Sciences, Biochemistry, Chemistry +9