Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

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Structure−Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists

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Medicine, Medicinal Chemistry, Pharmacology +15

Effect of Rimonabant on the High-Triglyceride/ Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat

Jean‐Pierre Després, Robert Ross, Gabor Boka et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2008 · 201 citations · Full text

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SERENADE: The Study Evaluating Rimonabant Efficacy in Drug-Naive Diabetic Patients

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Endocannabinoids and Their Receptors as Targets for Obesity Therapy

Annette D. de Kloet, Stephen C. Woods · Endocrinology · 2009 · 43 citations

Medicine, Pharmacology, Pharmacotherapy +17