Science · 1981 · 487 citations · 15 references
Life SciencesCell BiologyMicrobiologyMolecular VirologyMucosal ImmunologyVirologyViral AttachmentViral EntryViral InfectionsViral PathogenesisVirus EntryVirus-host InteractionsAdhesion To Intestinal CellsGastrointestinal Viral InfectionsGastrointestinal Viral PathogenesisM CellsViral Adhesion To Mucosal SurfacesViral Entry MechanismsViral Penetration MechanismsVirus Internalization
Thirty minutes after inoculation of reovirus type 1 into the intestinal lumen of the mouse, viruses were found adhering to the surface of intestinal M cells but not other epithelial cells. Within 1 hour, viruses were seen in the M cell cytoplasm and were associated with mononuclear cells in the intercellular space adjacent to the M cell. These findings suggest that M cells are the site where reovirus penetrates the intestinal epithelium.
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