Detection of <scp>ALK</scp> expression in non‐small‐cell lung cancer with <i><scp>ALK</scp></i> gene rearrangements – comparison of multiple immunohistochemical methods

Abstract

ALK immunohistochemistry can be considered as a pre-screen method if one accepts a sensitivity of 93.3-96.6%. Because ALK immunohistochemical staining needs to be performed close to the detection limit of the assay, vigilant quality control monitoring is required to guarantee trustworthy results.