Serum with phospholipase <scp>A</scp>2 receptor autoantibodies interferes with podocyte adhesion to collagen

Abstract

We demonstrated that serum of patients containing autoantibodies directed to PLA2R interferes with the ability of podocytes to attach to collagen type IV in vitro, providing evidence of a serum soluble pathogenic factor interfering with podocyte adhesion in membranous nephropathy.