FEBS Letters · 1984 · 105 citations · 25 references
Life SciencesBiochemistryMolecular BiologyCell SignalingEnzymologySignal TransductionEnzyme KineticsEnzyme RegulationHormone SecretionPancreatic EndocrinologyPancreatic HormonesSecretory PathwayAmylase ProductionAmylin SecretionPancreatic Digestive EnzymesPancreatic Hormone SecretionPancreatic Islet FunctionPancreatic Islet SecretionPancreatic SecretionPancreatic Secretory Response
The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.
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