Journal of Cardiovascular Pharmacology · 1981 · 82 citations · 0 references
PharmacyPharmacologyPharmacotherapyCardiovascular PharmacotherapyClinical PharmacologyPharmacodynamicsBlood Pressure ControlBlood Pressure ManagementDiuretic TherapyHypertension ControlHypertension ManagementHypertension PharmacotherapyAntihypertensive Drug TherapyAntihypertensive Medication ManagementAntihypertensive PharmacologyBlood PressureDiuretic MechanismsHypertensive Drug ResponsePlasma Renin ActivityThiazide Diuretic Therapy
A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell about 14/11 mm Hg during treatment with either drug compared to the placebo period, and neither drug caused significant side effects. Verapamil did not affect plasma renin concentration.