Point-of-Care Assessment of Hypothermia and Protamine-Induced Platelet Dysfunction with Multiple Electrode Aggregometry (Multiplate®) in Patients Undergoing Cardiopulmonary Bypass

Abstract

Platelet aggregation, assessed by multiple electrode aggregometry (Multiplate), was severely affected during deep, whole-body hypothermia. This effect was partially reversible after rewarming, and was distinct from a general decline of platelet aggregation during CPB. Protamine also caused a significant decrease in platelet aggregation in vivo and in vitro.