Chemistry Letters · 2014 · 13 citations · 42 references
PharmacyMedicinal ChemistryMolecular BiologyDrug DesignDrug DiscoveryMolecular ImagingChemical Probe DiscoveryLigand BindingMolecular Probe DevelopmentProtein TargetingProtein-ligand RecognitionTargeted Imaging AgentsAffinity-based ProbesLabelingMolecular Imaging Probe DesignMolecular Targeting LigandsProtein FunctionalizationProtein Labeling ChemistrySmall-molecule Imaging ProbesTargeted Molecular Probes
Abstract We successfully extended affinity-guided DMAP (AGD) chemistry with a reactivity-tuned acyl donor library that is capable of the selective and efficient labeling of FKBP12 in living cells as well as in test tube. The new AGD chemistry provides great promise for the establishment of selective intracellular protein functionalization or imaging methods.
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
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Cell Surface Engineering by a Modified Staudinger Reaction
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