Novel synthesis of phthalazine derivatives as antimicrobial agents

Abstract

Reaction of 4-(phenoxathiin-2-yl)-1-oxy or mercaptophthalazines 2a,c with phthalyl or tosylamino acids 3 and 4 has been found to yield 5,6a-j . Hydrazinolysis of 5,6a-e furnished amino derivatives 5,6k-o . Some of the newly synthesized products were tested for their antimicrobial activities.