Palladium‐Catalyzed Oxidative Trifluoromethylation of Indoles at Room Temperature

Abstract

Trifluoromethylation of indoles has been performed successfully at room temperature by using a novel palladium-catalyzed oxidation strategy. In this reaction, PhI(OAc)2 has been used as an oxidant and TMSCF3 as a trifluoromethylation reagent (see scheme). A palladium(II/IV) mechanism has been proposed for the formation of the aryl CCF3 bond.