26Al tracer experiment by accelerator mass spectrometry and its application to the studies for amyotrophic lateral sclerosis and Alzheimer's disease. I.

Abstract

Accelerator mass spectrometry (AMS) was applied for 26Al tracer experiment to study the aluminum toxicity and metabolism in rats. To investigate the cause of amyotrophic lateral sclerosis (ALS) and Alzheimer's disease, the aluminum incorporation into the brain (cerebrum) was studied by AMS using 26Al as a tracer. When 26Al was intraperitoneally injected into rats, a considerable amount of 26Al was incorporated into the cerebrum after 5-35 days of the injection.