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Synthesis and enantioselective fluorodehydroxylation reactions of (S)-2-(methoxymethyl)pyrrolidin-1-ylsulphur trifluoride, the first homochiral aminofluorosulphurane
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1989
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Medicinal ChemistryBioorganic ChemistryBiochemistryPyrrolidin-1-ylsulphur TrifluorideNatural SciencesFluorous SynthesisOrganic ChemistryStable AminofluorosulphuranesChemistryFirst Homochiral AminofluorosulphuraneEnantioselective Fluorodehydroxylation ReactionsPharmacologyHeterocycle ChemistryDerivative (Chemistry)Synthetic ChemistryEnantioselective Synthesis
(S)-2-(Methoxymethyl)pyrrolidin-1-ylsulphur trifluoride (7), the first homochiral aminofluorosulphurane and one of the most stable aminofluorosulphuranes yet reported, has been prepared, and has been shown to be an effective enantioselective fluorodehydroxylating agent.