Concepedia

Stereoselective Synthesis of Pyrrolidines from <i>N</i>-Allyl Oxazolidines via Hydrozirconation−Cyclization

Jean‐Luc Vasse, Antoine Joosten, Clément Denhez, Jan Szymoniak

Organic Letters · 2005 · 38 citations · 13 references

DOI

Abstract

[reaction: see text] A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation-stereoselective Lewis acid mediated cyclization sequence.

References

13

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Brønsted Acid-Catalyzed Intramolecular Hydroamination of Protected Alkenylamines. Synthesis of Pyrrolidines and Piperidines

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Intramolecular Hydroamination of Unactived Olefins with Ti(NMe<sub>2</sub>)<sub>4</sub> as a Precatalyst

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