Chronic prenatal stress epigenetically modifies spinal cord<scp>BDNF</scp>expression to induce sex‐specific visceral hypersensitivity in offspring

Abstract

The development of VHS, which contributes to the symptom of intermittent abdominal pain, is a two-step process, chronic in utero stress followed by chronic stress in adult-life. This two-step process induces aggravated and persistent colon hypersensitivity in female than in male offspring. Our preclinical model explains several clinical features in IBS patients.