New quinoxaline and pyrimido[4,5‐b]quinoxaline derivatives. Potential antihypertensive and blood platelet antiaggregating agents

Abstract

Abstract Starting with 3‐amino‐2‐quinoxalinecarbonitrile 1,4‐dioxide 1 , a new series of quinoxaline derivatives 2‐12 was synthetized through chemical modification of the 3‐amino group, the 2‐cyano group and selective mono‐deoxygenation of the 1‐oxide or 4‐oxide groups. On the other hand, two 2,4‐diaminopyrimido[4,5‐ b ]quinoxa‐line derivatives 13, 14 were obtained condensing 3‐amino‐2‐quinoxaline carbonitriles with quanidine. Some of the new compounds were studied as inhibitors of blood platelet aggregation as well as antihypertensive agents.