Modulation of immunoreactive protein kinase C-α and β isoforms and G proteins by acute and chronic treatments with morphine and other opiate drugs in rat brain

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

Mark A. Bradford · Analytical Biochemistry · 1976 · 225.4K citations

Life Sciences, Biochemistry, Protein Biochemistry +7

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.3K citations

Life Sciences, Biochemistry, Molecular Biology +12

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

Toshiaki Katada, Alfred G. Gilman, Yasuhiro Watanabe et al. · European Journal of Biochemistry · 1985 · 735 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

S K Sharma, Werner A. Klee, Marshall W. Nirenberg · Proceedings of the National Academy of Sciences · 1975 · 669 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

K Raynor, Hyesik Kong, Yong Chen et al. · Molecular Pharmacology · 1994 · 663 citations · Full text

Medicine, Pharmacology, Molecular Pharmacology +16