The Open Pharmacology Journal · 2008 · 23 citations · 0 references
PharmacyPharmacokineticsPharmacologyChemotherapyPharmacokinetic VariabilityPharmacokinetics Of Anticancer AgentsAnimal Models In PharmacologyDrug DispositionPharmacokinetic SamplingPharmacokinetics Of Anticancer DrugsPreclinical Drug EvaluationRodent PharmacologyBleedingCyclophosphamide DosingPharmacokinetic ParametersPharmacokinetics Of Cytotoxic ChemotherapySample Preparation MicrodevicesVeterinary PharmacokineticsWhole Blood CollectionWhole Blood Separation
Preclinical studies on pharmacokinetics in animals usually require at least 3-5 animals per time point. The use of several animals in each time point may increase the result variation due to individual dosing errors and inter-and intraindividual variation among animals. Moreover, a large number of animals has to be euthanized in these experiments.