Resolution of Enantiomers by HPLC on Optically Active Poly(triphenylmethyl Methacrylate)

Abstract

Abstract Optically active (+)-poly(triphenylmethyl methacrylate) (PTrMA) which has the chirality due to only helicity has been used as two different types of chiral stationary phases for resolving enantiomers by HPLC. One was prepared with the insoluble (+)-PTrMA ground to small particles and the other by adsorbing the soluble polymer on macroporous silica gel. These stationary phases, particulary the latter, resolved a wide variety of enantiomers including hydrocarbons, esters, amides, halides, phosphoric compounds and so on by using a polar eluent like methanol.