Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria

Detection of specific sequences among DNA fragments separated by gel electrophoresis

E.M. Southern · Journal of Molecular Biology · 1975 · 32.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Geoffrey M. Wahl, Michael Stern, George R. Stark · Proceedings of the National Academy of Sciences · 1979 · 3.4K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

A SIMPLE PHENYLALANINE METHOD FOR DETECTING PHENYLKETONURIA IN LARGE POPULATIONS OF NEWBORN INFANTS

Robert Guthrie, Ada Susi · PEDIATRICS · 1963 · 2.2K citations

Medicine, Pediatrics, Early Detection +7

Nucleotide sequence of the rightward operator of phage lambda.

Tom Maniatis, Andrea Jeffrey, Dennis G. Kleid · Proceedings of the National Academy of Sciences · 1975 · 2.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

Stuart H. Orkin, Haig H. Kazazian, Stylianos E. Antonarakis et al. · Nature · 1982 · 934 citations

Life Sciences, Genetics, Molecular Genetics +11