Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Pere Puigserver, Zhidan Wu, Cheol Won Park et al. · Cell · 1998 · 3.8K citations · Full text

Signal Transduction, Receptor (Biochemistry), Molecular Biology +4

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature · 2004 · 2.7K citations

Aging, Mitochondrial Function, Longevity +3

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

Gregory C. Kujoth, Asimina Hiona, Thomas D. Pugh et al. · Science · 2005 · 2.1K citations

Aging, Mitochondrial Function, Mitochondrial Dynamic +12

Activation of the human mitochondrial transcriptionfactor A gene by nuclear respiratory factors: a potential regulatory linkbetween nuclear and mitochondrial gene expression in organellebiogenesis.

Joseph V. Virbasius, Richard C. Scarpulla · Proceedings of the National Academy of Sciences · 1994 · 792 citations · Full text

Human Mttfa Gene, Genetics, Molecular Genetics +16

Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease

Inna I. Kruman, T. S. Kumaravel, Althaf Lohani et al. · Journal of Neuroscience · 2002 · 643 citations · Full text

Alzheimer's Disease, Folic Acid Metabolism, Biochemistry +13