Two-Vial, LC−MS Identification of Ephedrine Receptors from a Solution-Phase Dynamic Combinatorial Library of over 9000 Components

Abstract

Reports on dynamic combinatorial chemistry have almost exclusively involved small libraries of 10-100 compounds. We now show how more than 9000 compounds can be screened in a single LC-MS analysis to reveal a series of new receptors that bind ephedrine in water. These results demonstrate the feasibility of screening DCLs that are substantially larger than the solution-phase libraries reported thus far.