Synthesis · 2006 · 19 citations · 0 references
PharmacyChemistryMedicinal ChemistryBioorganic ChemistryOrganic ChemistrySynthetic Medicinal ChemistryMacrocycle SynthesisOrganic SynthesisC - H Bond FunctionalizationChemical Synthesis Of AnaloguesMedicinal Chemistry ApplicationsNatural Product SynthesisNucleoside Analog SynthesisSynthetic Analogues
The synthesis of cyclic bis(3′-5′)diguanylic acid (c-di-GMP) by using a new flexible approach is reported. The flexibility of the method is exemplified by the synthesis of base-modified analogues that will find applications in the elucidation of c-di-GMP biological modes of action.