L-Arginine Decreases Alveolar Macrophage Proinflammatory Monokine Production during Acute Lung Injury by a Nitric Oxide Synthase-Dependent Mechanism

Abstract

(1) L-Arginine is an immunomodulating nutritional supplement; (2) L-arginine decreases alveolar macrophage proinflammatory monokine production during ETX-induced acute lung injury by a nitric oxide synthase-dependent mechanism; and (3) the provision of exogenous substrate for local NO production may reduce inflammation during acute lung injury.