Proceedings of the National Academy of Sciences · 1977 · 112 citations · 19 references
Life SciencesGeneticsMolecular GeneticsCytogeneticsHuman GeneticsMicroevolutionChromosome SegregationHybridizationChromosome Behavior In HybridsChromosome Segregation In HybridsCytogenetic Analysis Of HybridsRibosomal Dna Copy Number Control
Mouse-human somatic cell hybrids that lose (segregate) human chromosomes produce only mouse 28S ribosomal RNA even when they retain copies of the human chromosomes that contain the genes for 28S ribosomal RNA. In contrast, mouse-human hybrid cells that segregate mouse chromosomes produce only human 28S ribosomal RNA even when they have retained copies of mouse chromosomes that contain the 28S ribosomal RNA genes.
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