Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-α and iNOS expression, which is mediated by NF-κB regulation, in RAW264.7 cells

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Aspirin-like Drugs, Prostaglandin Synthesis, Biochemistry +8

NF-κB: Ten Years After

Patrick A. Baeuerle, David Baltimore · Cell · 1996 · 3K citations · Full text

Inflammation, Autoimmune Disease, Disease Mechanism +7

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

Q.W. Xie, Yumiko Kashiwabara, Carl Nathan · Journal of Biological Chemistry · 1994 · 2.2K citations · Full text

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Karen Seibert, Y Zhang, K. Leahy et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations · Full text

Pain Medicine, Immunology, Molecular Pain +22

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Jaime L. Masferrer, Ben S. Zweifel, Pamela T. Manning et al. · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations · Full text

Inflammation, Molecular Pharmacology, Selective Inhibition +14