Asymmetric Synthesis of Cyclic <i>cis</i>-β-Amino Acid Derivatives Using Sulfinimines and Prochiral Weinreb Amide Enolates

Abstract

Cyclic cis-beta-amino Weinreb amides, valuable building blocks for the asymmetric synthesis of cyclic beta-amino acids derivatives, are readily prepared via ring-closing metathesis of sulfinimine-derived N-sulfinyl beta-amino diene Weinreb amides. These unsaturated cyclic cis-beta-amino Weinreb amides are valuable building blocks for the asymmetric synthesis of cyclic beta-amino acid derivatives.