Pathophysiology of Haemostasis and Thrombosis · 2009 · 39 citations · 0 references
MedicineHematologyPharmacologyAutoimmunityHematopathologyHemostasisAnticoagulant TherapyAntiphospholipid SyndromePlatelet DisordersPlatelet PhysiologySystemic Lupus ErythematosusThrombosisAnticoagulant MechanismsAnticoagulant PharmacologyAntiphospholipid Syndrome AnticoagulationHemorrhagic ManifestationsHemostatic Plug FormationLupus Anticoagulant EffectsPlasma Anticoagulant ActivityPlatelet Plug Formation
Seven patients, four of whom have proven DLE, are described with a circulating anticoagulant displaying antiphospholipid activity. The anticoagulant effect is decreased when the patient sample is added in a more diluted form and can be overwhelmed by a phospholipid preparation of high potency. This explains for the absence of hemorrhagic symptoms in these patients because a vast excess of platelet phospholipid is liberated during platelet plug formation. Furthermore the inhibitor does not protect against thrombosis.