Establishing a Flow Process to Coumarin‐8‐Carbaldehydes as Important Synthetic Scaffolds

Abstract

Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin-8-carbaldehydes are lacking. We describe here a high-yielding continuous flow synthesis that requires no manual intermediate purification or work-up, giving access to multigram quantities of the aldehyde product.