Uncovering a Latent Ligation Site for Glycopeptide Synthesis

Abstract

Serine in site: A native chemical ligation concept at the serine site is described (see picture). This method was achieved by the CNBr conversion reaction from methylcysteine, which could be obtained by selective S methylation. This new method allowed a consensus sequence that is generally incorporated in N-linked oligosaccharides to be used as a ligation site in the course of glycopeptide synthesis. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801097_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.