Thyroid Abnormalities After Radiation Exposure in Infancy

Abstract

Article1 June 1967Thyroid Abnormalities After Radiation Exposure in InfancyRALPH A. PINCUS, M.D., F.A.C.P., SEYMOUR REICHLIN, M.D., PH.D., L. H. HEMPELMANN, M.D.RALPH A. PINCUS, M.D., F.A.C.P.Search for more papers by this author, SEYMOUR REICHLIN, M.D., PH.D.Search for more papers by this author, L. H. HEMPELMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1154 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEpidemiologic studies have clearly shown that radiation exposure plays a role in the induction of thyroid neoplasms in man (reviewed in references 1 and 2). In these studies, it has been observed that a large proportion of children and young adults with cancer of the thyroid give a history of prior X-ray treatment to the neck region and that the prevalence of thyroid cancers, adenomas, and nodules in irradiated populations is higher than in nonirradiated groups.Although greatly in excess of that expected, the prevalence of thyroid neoplasms in irradiated groups reported in most prospective surveys is believed to be...References1. Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, Supplement no. 14 (A/5814). United Nations, New York, 1964. Google Scholar2. PIFERHEMPELMANN JWLH: Radiation-induced thyroid carcinoma. Ann. N. Y. Acad. Sci. 114: 838, 1964. CrossrefGoogle Scholar3. SOCOLOWHASHIZUMENERIISHINIITANI ELASR: Thyroid carcinoma in man after exposure to ionizing radiation. A summary of the findings of Hiroshima and Nagasaki. New Eng. J. Med. 268: 406, 1963. CrossrefMedlineGoogle Scholar4. CONARDRALLSUTOW RAJEWW: Thyroid nodules as a late sequelae of radioactive fallout in a Marshall Island population exposed in 1954. New Eng. J. Med. 274: 1391, 1966. CrossrefMedlineGoogle Scholar5. PIFERTOYOOKAMURRAYAMESHEMPELMANN JWETRWWRLH: Neoplasms in children treated with X rays for thymic enlargement. I. Neoplasms and mortality. J. Nat. Cancer Inst. 31: 1333, 1963. MedlineGoogle Scholar6. TOYOOKAPIFERCRUMPDUTTONHEMPELMANN ETJWSLAMLH: Neoplasms in children treated with X rays for thymic enlargement. II. Tumor incidence as a function of radiation factors. Ibid., p. 1357. Google Scholar7. HEMPELMANNPIFERBURKETERRYAMES LHJWGJRWR: Neoplasms in persons treated with X rays in infancy for thymic enlargement. A report of the third follow-up survey. J. Nat. Cancer Inst. 38: 317, 1967. MedlineGoogle Scholar8. BARKERHUMPHREYSOLEY BSMJMH: The clinical determination of protein-bound iodine. J. Clin. Invest. 30: 55, 1951. CrossrefMedlineGoogle Scholar9. SIEGEL S: The Mann-Whitney U test, in Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill Book Co., New York, 1956. Google Scholar10. CONARD RA: Personal communication. Google Scholar11. DONIACH I: Experimental induction of tumors of the thyroid by radiation. Brit. Med. Bull. 14: 181, 1958. CrossrefMedlineGoogle Scholar12. MARKSBUSTAD SLK: Thyroid neoplasms in sheep fed radioiodine. J. Nat. Cancer Inst. 30: 661, 1963. Google Scholar13. VANDERGASTONDAWBER JBEATR: Significance of solitary nontoxic thyroid nodules. New Eng. J. Med. 251: 970, 1954. CrossrefMedlineGoogle Scholar14. MATOVINOVICHAYNEREPSTEINKJELSBERG JNSFHMD: Goiter and other thyroid diseases in Tecumseh, Michigan; studies in a total community. JAMA 192: 234, 1965. CrossrefMedlineGoogle Scholar15. WINSHIPROSVOLL TRV: Childhood thyroid carcinoma. Cancer 14: 734, 1961. CrossrefMedlineGoogle Scholar16. CARROLLHADDONHANDYWIEBEN REWVHEE: Thyroid cancer: cohort analysis of increasing incidence in New York State, 1941-1962. J. Nat. Cancer Inst. 33: 277, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New YorkFrom the Departments of Radiology and Internal Medicine, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.This investigation was supported by research grant RH 00210, National Center for Radiological Health, and endocrinology training grant TI AM 5022, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Ralph A. Pincus, M.D., 797 Elmwood Ave., Rochester, N. Y. 14620. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyroidIodine-123 scintigraphy in the evaluation of pediatric thyroid disorders: A ten year experienceLymph node metastasis from papillary-follicular thyroid carcinoma in young patientsTHYROID FUNCTION IN PATIENTS WITH MYOTONIC DYSTROPHYRadiation Effects on the Thyroid GlandThyroid Nodules in ChildrenLate sequelae of superficial irradiationRetrospective and prospective study of radiation-induced thyroid diseaseRisk factors for thyroid abnormalities after neck irradiation for childhood cancerTHYROID ABNORMALITIES IN PATIENTS WITH MYOTONIC DYSTROPHYHead and neck neoplasia following irradiation for benign conditionsCyclical combination chemotherapy and thyroid function in patients with advanced hodgkin's diseaseDo All Nodules Appearing in Patients Subsequent to Radiation Therapy to the Head and Neck Areas Require Excision?Reactions to ionizing radiationNon-Hodgkin's Lymphoma of the ThyroidEpidemiologyThe Approach to the Irradiated ThyroidRadiation exposure during panoramic radiography in childrenIncidence, prevalence and characteristics of radiation-induced thyroid tumorsThyroid cancer classification, clinical features, diagnosis and therapyManagement of thyroid nodules in the elderlyThyroid Cancer Occurring as a Late Consequence of Head-and-Neck IrradiationLong-term effects of external radiation on the pituitary and thyroid glandsThyroid uptake of 1311 following hippuran renal scintillation camera studies in children blackwellThyroid tumor risk from radiation during childhoodContinuing Occurrence of Thyroid Carcinoma after Irradiation to the Neck in Infancy and ChildhoodExperimental Thyroid CarcinogenesisThyroid nodularity in Southwestern Utah school children exposed to fallout radiation.Die Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenCarcinoma of the thyroid after external radiation to the neck in adultsCarcinoma of the Thyroid in ChildrenTHYROID PROLIFERATIVE POTENTIAL AS A FUNCTION OF AGERisk of Thyroid Neoplasms after Irradiation in ChildhoodNeoplasms in youthful populations following X-ray treatment in infancy 1 June 1967Volume 66, Issue 6Page: 1154-1164KeywordsCancer treatmentHead and neck cancersInfantsPopulation statisticsProteinsRadiation exposureResearch grantsThyroidThyroid carcinomaYoung adults ePublished: 1 December 2008 Issue Published: 1 June 1967 PDF downloadLoading ...