Biomacromolecules · 2005 · 166 citations · 23 references
EngineeringBioengineeringBiomedical EngineeringBiocompatibilityDrug DeliveryTissue EngineeringGelsHydrogelsNanomaterials For Drug DeliveryPolymeric Drug Delivery SystemsPolymerization ChemistrySupramolecular GelsAtom Transfer Radical PolymerizationDrug Delivery GelsGelation MechanismsPhysical GelsThermo-responsive HydrogelsThermoresponsive GelsThermoresponsive HydrogelsThermoresponsive Polymeric Carriers
The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiator. These novel triblock copolymers are water-soluble in dilute aqueous solution at 20 degrees C and pH 7.4 but form free-standing physical gels at 37 degrees C due to hydrophobic interactions between the poly(N-isopropylacrylamide) blocks. This gelation is reversible, and the gels are believed to contain nanosized micellar domains; this suggests possible applications in drug delivery and tissue engineering.
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Comb-type grafted hydrogels with rapid deswelling response to temperature changes
Ryo Yoshida, Katsumi Uchida, Yuzo Kaneko et al. · Nature · 1995 · 1.2K citations
Natural Sciences, Materials Engineering, Materials Science +12