Proceedings of the National Academy of Sciences · 2010 · 234 citations · 42 references
Life SciencesPlant BiologyPlant SciencesInnate ImmunityPlant Molecular BiologySignal TransductionInnate Immune ResponseInnate Immune Signaling PathwaysPlant Defense ResponsesPlant Immune ResponsesPlant Immune SignalingPlant Transcriptional RegulationLeucine-rich Repeat Receptor-like KinasesPamp RecognitionPathogen Response SignalingPathogen-associated Molecular Pattern RecognitionPathogen-associated Molecular Pattern SensingPathogen-associated Molecular Pattern SignalingPlant Resistance Signaling PathwaysTranscriptional Regulation Of Immunity
In plant innate immunity, the leucine-rich repeat receptor kinase FLS2 recognizes the bacterial pathogen-associated molecular pattern (PAMP) flagellin. The molecular mechanisms underlying PAMP perception are not fully understood. Here, we reveal that the gaseous phytohormone ethylene is an integral part of PAMP-triggered immunity. Plants mutated in the key ethylene-signaling protein EIN2 are impaired in all FLS2-mediated responses, correlating with reduced FLS2 transcription and protein accumulation. The EIN3 and EIN3-like transcription factors, which depend on EIN2 activity for their accumulation, directly control FLS2 expression. Our results reveal a direct role for ethylene in regulation of an innate immune receptor.
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