Concepedia

DDQ-Mediated Direct Cross-Dehydrogenative-Coupling (CDC) between Benzyl Ethers and Simple Ketones

Yuhua Zhang, Chao‐Jun Li

Journal of the American Chemical Society · 2006 · 409 citations · 16 references

DOI

Concepts

Abstract

A direct Cross-Dehydrogenative-Coupling (CDC) between benzyl ethers and simple ketones was developed without using any metal catalyst. By using DDQ, various benzyl ethers and simples ketones were coupled together directly to form beta-alkoxyl ketones efficiently. A mechanism in which the DDQ serves the double roles of an oxidizing agent and an organomediator was proposed.

References

16

CuBr-Catalyzed Efficient Alkynylation of sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2004 · 665 citations

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Highly Efficient Copper-Catalyzed Nitro-Mannich Type Reaction:  Cross-Dehydrogenative-Coupling between sp<sup>3</sup> C−H Bond and sp<sup>3</sup> C−H Bond

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2005 · 538 citations

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CuBr-Catalyzed Direct Indolation of Tetrahydroisoquinolines via Cross-Dehydrogenative Coupling between sp<sup>3</sup> C−H and sp<sup>2</sup> C−H Bonds

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2005 · 505 citations

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Catalytic Enantioselective Alkynylation of Prochiral sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom

Zhiping Li, Chao‐Jun Li · Organic Letters · 2004 · 365 citations

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Highly Efficient Cross‐Dehydrogenative‐Coupling between Ethers and Active Methylene Compounds

Yuhua Zhang, Chao‐Jun Li · Angewandte Chemie International Edition · 2006 · 285 citations

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