Immunohistochemical study of syndecan‐1 down‐regulation and the expression of p53 protein or Ki‐67 antigen in oral leukoplakia with or without epithelial dysplasia

Abstract

Our results reveal that overexpression of p53 protein and Ki-67 antigen, and down-regulation of syndecan-1 expression in the lower part of the epithelium, are associated with dysplastic changes. Therefore, the down-regulation of syndecan-1 expression may be the most important reliable marker for dysplastic changes.